Lumi – CMax:
Master Your Mammalian & Stem Cell Culture
Overview
Value Proposition
Designed specifically for the nuances of cell culture, the Lumi – CMax ensures optimal mixing and oxygen transfer with minimal shear stress. Its modular, configurable vessels from 2.5L to 14L and specialized impellers simplify operation and maintenance while promoting high cell densities and viability.
Application-Specific Impellers
Choose from a range of application-specific impellers tailored to your process requirements, ensuring optimal mixing, oxygen transfer, and scalability for every cultivation need.
Basket
Impeller
- Designed for use with microcarrier discs
- Low shear or minimal shear stirring system
- Promotes larger adhesion area and strong cell adherence ability
- No requirement to pre-treat the microcarriers Execute complex DoE
Cell-Lift
Impeller
- Promotes higher cell density
- Features larger cell adherence area for optimized growth
- Specifically designed and better suited for perfusion cell culture applications
- Enhances nutrient circulation future scale-up
Pitched-Blade
Impeller
- Low-Shear Fluid Dynamics
- Simultaneous Axial and Radial
- Efficient Microcarrier Suspension
- Enhanced Oxygen Mass Transfer
Features
Adaptive Vessel Design
- Swappable Impeller System: Ships with options for Pitched-blade (suspension/microcarriers), Cell-lift (ultra-low shear for high-density microcarriers), and Basket impellers (for fabric carriers). Adapts to your process in minutes.
- Premium Borosilicate Vessels: Choose between single-wall heating blanket configurations (with optional cooling loop) or high-borosilicate water-jacketed vessels paired with external TCU chillers for accurate temperature control.
- Universal Headplate: Highly customizable port configuration (19mm & PG13.5) accommodating temperature probes, feeding tubes, and analog/optical pH and DO sensors.
Advanced Gas and Fluid Control
- Precision 4-Gas Mixing: Integrated Thermal Mass Flow Controllers (TMFC) for Air, O₂, N₂, and CO₂, ensuring exact dissolved oxygen and pH buffering.
- Integrated Pumping Station: Four built-in, front-facing fixed/variable-speed peristaltic pumps dedicated to feeding, acid/base addition, and antifoam, minimizing the need for external equipment
- Customized Sparging: Standard ring sparger with options to upgrade to micro-bubble or microporous spargers for optimized oxygen transfer rates (OTR).
LumiWise Advanced Automation & Compliance
LumiWise combines powerful automation, intuitive process control, and regulatory-ready compliance in a single platform. Advanced cascade control enables automatic linking of PID loops, allowing DO to dynamically control agitation, oxygen enrichment, or gas flow.
Designed for GMP environments, LumiWise supports 21 CFR Part 11 compliance with electronic records, electronic signatures, audit trails, and role-based access control.
Smarter Automation. Greater Compliance. Better Process Control.
Technical Specifications
Controller & Utilities
| Communications | 2 USB (for software update, serial communication) |
|---|---|
| Power | AC 220V, 50/60 Hz, 5.8A |
| Water | 10 psig (0.7 bar) |
| Gas (Air, O2, CO2 and N2) | 10 psig (0.7 bar) |
| Exhaust | 0.5 psig (0.035 bar) |
| Operating Temperature | 10-32°C, no more than 80% relative humidity and no condensation |
| Controller Dimensions | 70cm H x 39cm W x 54cm D |
System Components
| Agitation | Magnetic Drive, 25-300rpm for 1L to 5L, 25-150rpm for 10L |
|---|---|
| Temperature Control | Water Jacket or Heating Blanket (5°C above coolant temperature to max 60°C) Heating Blanket |
| Probe | Pt100 |
| Gas Sparging & Overlay | 1, 3 or 4 TMFC, ring or microbubble sparger, overlay with 1 TMFC or rotameter |
| Peristaltic Pumps | Fixed speed (25 rpm) or Variable speed (25-200 rpm) |
Sensors
| pH | 2-12 |
|---|---|
| DO | 0-200% |
| Optical DO | 0-200% |
| Redox | (- 2000mv) – (+ 2000mv) |
| CO2 | 0 -100% |
| Optional | Total Cell Density, Viable Cell Density, Conductivity, etc. |
Vessel Design Specifications
| Total Volume |
2.5L | 5.0L | 7.5L | 14.0L |
|---|---|---|---|---|
| Working Volume |
0.6 – 1.9L | 1.3 – 3.8L | 1.9 – 5.6L | 3.5 – 10.5L |
| Vessel | Single-walled or jacketed | |||
| Material | Borosilicate glass and 316 stainless-steel | |||
| Impeller | Pitched-blade, cell lift, packed-bed basket | |||
Resources
Please fill in the form below and we will send you a link to download the e-catalogue.