Lumi SIP:
Precision Engineered for Performance

Overview

Value Proposition

The Complete Solution for Pilot-Scale Fermentation
  • A mobile fermentation/bioreactor system designed for pilot-scale and small-scale production in R&D, biopharma labs, and platform facilities.
  • Features a proprietary LumiWise control algorithm that automates and precisely regulates the entire process, from start to finish.
  • Built with premium components from internationally renowned brands to ensure reliable quality and stable performance under high operational loads.
  • Delivers stable process control, a clean exterior design, an intuitive human-machine interface.

Precision in Motion: Agitation

  • Top or bottom-stirring configuration with double-end mechanical seals.
  • Standard configuration includes multi-stage impellers.
  • Variable speed control

Automatic Vessel Pressure Control

  • Fully automated pressure regulation.
  • Manual regulating valve with an automatic option available.
  • Independent pressure display panel for clear monitoring of utilities.

Quality in Action: Verification at Every Step

  • All raw materials verified via .
  • 100% of pipeline welds inspected with a video borescope.
  • Surface roughness of all wetted parts measured and documented.
Features
Vessel Construction
  • Vessel and all wetted parts constructed from 316L stainless steel.
  • Designed for efficient heat transfer and mixing.
  • Multiple ports for sensors and process additions.
  • Ergonomic features like a head plate translation and rotation mechanism for easy access.
Intelligent Automation for Every Process Step
  • The Lumi SIP is controlled by a powerful Siemens PLC system with an intuitive, colorful touch screen interface.
  • Our LumiWise, proprietary software provides complete control over every parameter, with dedicated modules for all process stages.
  • Features user-level management (Administrator, Operator, Supervisor) to ensure operational security.
  • Designed for process reproducibility and data integrity.
Automated Sterilization and Integrity for cGMP Compliance
  • Fully automated Sterilize-in-Place (SIP) cycle with customizable parameters.
  • Software includes a dedicated module for automated vessel integrity (pressure hold) testing before each run.
  • Optional cold spot monitoring and automatic F0 value calculation ensures compliance with regulatory requirements for sterilization validation.
Our Commitment to Quality: A Transparent and Rigorous Process
  • Every Lumi SIP fermenter is built according to a comprehensive Product Quality Plan.
  • The quality system covers every stage of production, from material procurement and design verification to final functional testing and packaging.
  • Key inspection points (Halt, Audit, Witness) are built into the manufacturing process to ensure standards are met.
  • Full documentation provides traceability for all critical components and processes.
LumiWise Advanced Automation & SCADA
  • Loop Cascade: Interlink PID controllers effortlessly. Dynamically bind DO% directly to agitation speed or O₂ flow, automatically ramping oxygen intake as metabolic activity spikes.
  • Intuitive HMI: An industrial-grade, full-color touchscreen provides clear parameter configuration, historical trend analysis, and data comparison tools at your fingertips.
  • Recipe Management: Create, upload, and download custom cultivation recipes.
Regulatory Compliance & Security

Built for GMP-Regulated Bioprocessing

LumiWise is designed to support GMP environments with full 21 CFR Part 11 compliance, including electronic records, electronic signatures, and role-based access control.

Enterprise-Grade Security and User Management

The platform provides multi-level user permissions, dual-authenticated electronic signatures, password policies, account lockout protection, and automatic session timeout to ensure secure operation and data integrity.

Comprehensive Data Integrity & Audit Compliance

Sensitive process data is protected through encryption, automated backup and recovery mechanisms, and software version control, ensuring traceability, security, and business continuity.

Technical Specifications

System Components
Agitation Top/Bottom Stirring Direct/Magnetic Drive, 50-500/700rpm as standard for microbial and 25-100/200 rpm as standard for cell culture
Impellers Rushton, pitched blade, packed bed basket, cell lift and spin filter (application dependant)
Temperature Control 10°C above coolant temperature to max 90°C, built-in automatic sterilization protocol
Probe Pt100
Pressure Automatic or manual pressure regulator
Gas Sparging & Overlay 1, 3 or 4 TMFC, ring or microbubble sparger, overlay with 1 TMFC or rotameter
Peristaltic Pumps Fixed speed (25 rpm) or Variable speed (25-200 rpm)
Sensors
pH 2-12, PID controlled, digital probe
DO 0-200%, PID controlled, digital probe
Optional Total Cell Density, Viable Cell Density, Conductivity, Redox, CO2, load cell etc.
Pumps
Fixed-Speed 4-fixed speed peristaltic pumps, for feeding of acid, alkali, antifoam etc.
Variable-Speed Optional, available as integrated or external
Utilities
Power AC220V 50/60Hz or AC380V 50/60Hz
Water 50um filtration
Industrial Steam 30-35psig
Pure Steam 30-35psig
Gases Air, O2, CO2 and N2 at 30-35psig
Select from any of our pre-configured vessel configurations to save time and cost on engineering design activity and lead time!
Microbial Culture Vessel Design Specifications
Total
Volume		 65L 125L
Working
Volume		 16L – 50L 31L – 100L
Material 316 stainless-steel, sterilizable-in-place (SIP)
Impeller Rushton, Pitched-blade, Spin Filter
Cell Culture Vessel Design Specifications
Total
Volume		 40L 75L 150L 300L
Working
Volume		 11L – 32L 19L – 60L 38L – 120L 76L – 240L
Material 316 stainless-steel, sterilizable-in-place (SIP)
Impeller Pitched-blade, Packed Bed Basket, Cell Lift, Spin Filter
Or alternatively come to us with your exact requirements or customization needs and we can build your system from ground up!

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